Development of Eosinophilia in dogs intradermically inoculated with sand fly saliva and Leishmania (Leishmania) chagasi stationary-phase promastigotes
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چکیده
منابع مشابه
A follow-up of Beagle dogs intradermally infected with Leishmania chagasi in the presence or absence of sand fly saliva.
In this study, we compare the development of infection and/or disease in Beagle dogs intradermally infected with Leishmania chagasi, in the presence or absence of Lutzomyia longipalpis saliva, with those of intravenously infected animals. Spleen samples of all the animals inoculated with parasites had positive polymerase chain reaction tests for Leishmania DNA. Positive spleen cultures for Leis...
متن کاملDifferential surface deposition of complement proteins on logarithmic and stationary phase Leishmania chagasi promastigotes.
Previous works demonstrated that various species of Leishmania promastigotes exhibit differential sensitivity to complement-mediated lysis (CML) during development. Upon exposure to normal human serum (NHS), cultures of Leishmania chagasi promastigotes recently isolated from infected hamsters (fewer than 5 in vitro passages) are CML-sensitive when in the logarithmic growth phase but become CML-...
متن کاملA killed Leishmania vaccine with sand fly saliva extract and saponin adjuvant displays immunogenicity in dogs.
A vaccine against canine visceral leishmaniasis (CVL), comprising Leishmania braziliensis promastigote protein, sand fly gland extract (SGE) and saponin adjuvant, was evaluated in dog model, in order to analyse the immunogenicity of the candidate vaccine. The vaccine candidate elicited strong antigenicity in dogs in respect of specific SGE and Leishmania humoral immune response. The major saliv...
متن کاملSand-Fly Saliva-Leishmania-Man: The Trigger Trio
Leishmaniases are worldwide diseases transmitted to the vertebrate host by the bite of an infected sand-fly. Sand-fly biting and parasite inoculation are accompanied by the injection of salivary molecules, whose immunomodulatory properties are actively being studied. This mini review focuses on how the interactions between sand-fly saliva and the immune system may shape the outcome of infection...
متن کاملInfluence of the Microenvironment in the Transcriptome of Leishmania infantum Promastigotes: Sand Fly versus Culture
Zoonotic visceral leishmaniasis is a vector-borne disease caused by Leishmania infantum in the Mediterranean Basin, where domestic dogs and wild canids are the main reservoirs. The promastigote stage replicates and develops within the gut of blood-sucking phlebotomine sand flies. Mature promastigotes are injected in the dermis of the mammalian host and differentiate into the amastigote stage wi...
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ژورنال
عنوان ژورنال: Memórias do Instituto Oswaldo Cruz
سال: 1993
ISSN: 0074-0276
DOI: 10.1590/s0074-02761993000200012